Blueroselady's Weblog

I wish you abundant happiness, health & wealth

Sleep deprivation makes one feeling high

leave a comment »

From Wikipedia:
Sleep deprivation, a sleep disorder characterized by having too little sleep, can be either chronic or acute. Long-term sleep deprivation causes death in lab animals.

A 2001 study at Chicago Medical Institute suggested that sleep deprivation may be linked to more serious diseases, such as heart disease and mental illnesses including psychosis and bipolar disorder. The link between sleep deprivation and psychosis (psychiatric disorders) was further documented in 2007 through a study at Harvard Medical School and the University of California at Berkeley. The study revealed, using MRI scans, that lack of sleep causes the brain to become incapable of putting an emotional event into the proper perspective and incapable of making a controlled, suitable response to the event.

A noted 2002 University of California animal study indicated that non-rapid eye movement sleep is necessary for turning off neurotransmitters and allowing their receptors to “rest” and regain sensitivity which allows monoamines (norepinephrine, serotonin and histamine) to be effective at naturally produced levels. This leads to improved regulation of mood and increased learning ability. The study also found that REM sleep deprivation may alleviate clinical depression because it mimics selective serotonin reuptake inhibitors (SSRIs).

What is REM and non-REM?

Sleep outside of the REM phase may allow enzymes to repair brain cell damage caused by free radicals. High metabolic activity while awake damages the enzymes themselves preventing efficient repair. This study observed the first evidence of brain damage in rats as a direct result of sleep deprivation.
REM deprivation had no significant effect on their ability to heal wounds.

Dreaming is rare during NREM sleep, and muscles are not paralyzed as in REM sleep. In addition, there is a parasympathetic dominance during NREM.

Fatal familial insomnia (FFI) is a very rare autosomal dominant inherited prion disease of the brain. It is almost always caused by a mutation to the protein PrPC, but it can also develop spontaneously in patients without the inherited mutation in a variant called sporadic fatal insomnia (SFI).

Sleep deprivation in INTERROGATION:
Sleep deprivation can be used as a means of interrogation, which has resulted in court trials over whether or not the technique is a form of torture. Under one interrogation technique, a subject might be kept awake for several days and when finally allowed to fall asleep, suddenly awakened and questioned. Menachem Begin, the Prime Minister of Israel from 1977-83, described his experience of sleep deprivation when a prisoner of the NKVD in Russia as follows: In the head of the interrogated prisoner, a haze begins to form. His spirit is wearied to death, his legs are unsteady, and he has one sole desire: to sleep… Anyone who has experienced this desire knows that not even hunger and thirst are comparable with it.

Sleep deprivation for depression treatment:
Recent studies show sleep deprivation has some potential in the treatment of depression, About 60% of patients, when sleep-deprived, show immediate recovery, with most relapsing the following night.

Why does sleep deprivation makes me feel high?
Sleep deprivation was found to enhance activity on the hypothalamic-pituitary-adrenal axis (which controls reactions to stress and regulates body functions such as digestion, the immune system, mood, sex, or energy usage) while suppressing growth hormones.

Manic individuals are often capable of long periods without sleep, or with very little sleep.
What is mania? Mania, the presence of which is a criterion for certain psychiatric diagnoses, is a state of abnormally elevated or irritable mood, arousal, and/ or energy levels.
Characteristics of mania include rapid speech, racing thoughts, decreased need for sleep, hypersexuality, euphoria, impulsiveness, grandiosity, and an uncontrollably intense interest in goal-directed activities. Some people also have physical symptoms, such as sweating, pacing, and weight loss.
Oh my goodness, I have all those characteristics.

One hypothesised cause of mania (among others), is that the amount of the neurotransmitter serotonin in the temporal lobe may be excessively high.
What does SEROTONIN do?
Serotonin or 5-Hydroxytryptamine (5-HT) is a monoamine neurotransmitter, biochemically derived from tryptophan, that is primarily found in the gastrointestinal (GI) tract, platelets, and central nervous system (CNS) of humans and animals. It is a well-known contributor to feelings of well-being.

The only sure and safe way to combat sleep deprivation is to increase nightly sleep time.

AIM: To sleep at least 6 hours per night.


Written by blueroselady

June 17, 2010 at 7:39 pm

Posted in health

Tagged with , ,

Leave a Reply

Fill in your details below or click an icon to log in: Logo

You are commenting using your account. Log Out /  Change )

Google+ photo

You are commenting using your Google+ account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )


Connecting to %s

%d bloggers like this: